News Feed www.cpc-researchschool.org News via RSS de www.cpc-researchschool.org Fri, 14 Dec 2018 22:13:39 +0100 Fri, 14 Dec 2018 22:13:39 +0100 TYPO3 EXT:news news-23845 Wed, 26 Sep 2018 14:49:08 +0200 Poster Award for Chaido Ori www.cpc-researchschool.orgnews-events/news/news/article/23845/index.html Chaido Ori, PhD student in the CPC Research School and in Micha Drukker's research group "Human Pluripotent Stem Cell Lineage Choice" at the Institute of Stem Cell Research at Helmholtz Zentrum München, received a poster award at the GSCN conference, which took place in Heidelberg from September 19-21, 2018. Chaido presented her poster entitled "Generation of lung organoids from hiPSC-derived multipotent lung progenitor cells" in the session "Stem cells in regenerative therapies". Congratulations!

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news-23844 Wed, 26 Sep 2018 14:42:18 +0200 Methods in Translational Research www.cpc-researchschool.orgnews-events/news/news/article/23844/index.html Date: October 24-26, 2018

MD and PhD students present fundamental biomedical methods and technologies, which they will use within the framework of their work. Topics and content are added on a relevant basis and include: Animal models, cell and tissue culture, functional analysis and cellular imaging, flow cytometry, immunohistochemistry, immunofluorescence, generation of antibodies, microscopy, nucleic acid analysis, protein analysis, protein-DNA interaction, protein-protein interaction, screening animals, transgene animals and knockout animals.

This presentation will be graded and constitutes 20% of the final grade for the introductory module.

This course is mandatory for all new MD and PhD students (class of 2018) and those who have not completed the course yet; everyone else is welcome to join.

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news-23843 Wed, 26 Sep 2018 10:24:00 +0200 Poster Award for Lin Yang www.cpc-researchschool.orgnews-events/news/news/article/23843/index.html Lin Yang, PhD student in Otmar Schmid's lab "Dynamics of Inflammatory Lung Diseases" at the ILBD, received a poster award at the NanoTox 2018 International Conference (http://nanotox2018.org/), which took place in Neuss from September 18-21, 2018. Lin presented his poster with the title "Novel imaging tools for deciphering pulmonary delivery and 3D cellular distribution of nanomaterials" in a session with over 130 posters in total. Congratulations, Lin!

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news-23819 Thu, 20 Sep 2018 14:29:51 +0200 German-French Lung Retreat in Paris, France, September 12-13, 2018 www.cpc-researchschool.orgnews-events/news/news/article/23819/index.html Shortly before the international ERS Congress, MD and PhD students and post-docs from the German-French Lung School met for a two-day-retreat in Paris to discuss scientific topics as well as to build up and foster their bilateral network.

The German-French Lung School was founded in 2013 as a cooperation between the German Center for Lung Research (DZL) and the French Institute National De La Santé Et De La Recherche Médicale (Inserm) with the aim of promoting young scientists and providing new impetus in international lung research. This year’s retreat was organized by Doreen Franke and Claudia Staab-Weijnitz (Helmholtz Zentrum München, CPC-M), as well as Nathalie Grivel, Christophe Guignabert, Marc Humbert, and Roger Marthan (Inserm). 

The event offered great opportunities for building new research connections. The conference started with a short welcome speech by Christian Boitard (IT / ITMO PMN), Marc Humbert, and Claudia Staab-Weijnitz from the organizing committee, followed by a keynote lecture given by Bradley Maron from the Brigham and Women's Hospital in Boston. During the evening event - a dinner cruise on the Seine - all participants had ample opportunities for networking and scientific discussions in a wonderful and scenic setting. 

On Thursday, the young scientists took the opportunity to present and discuss their results in scientifc sessions and in two poster sessions and walks, addressing a plethora of topics in repsiratory reaearch: Pulmonary Hypertension, Lung Fibrosis, Asthma & Allergy, Environmental Challenges for the Lung, Lung Cancer, and Novel Technologies in Experimental Lung Research and Bioengineering. 

The conference concluded with an informal career mentoring session accompanied with red and white wine. Antje Brand (CPC, Helmholtz Zentrum München), Peter Dorfmüller (University of Giessen and Inserm Paris), and Oliver Eickelberg (Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado, Anschutz Medical Campus) discussed important aspects of professional choices and shared advice on career decisions. As unique as the personal stories of each person were, they jointly agreed in one thing: Follow your aptitude and be passionate about what you do. Roger Marthan concluded the session with acknowledging all scientific contributions and a thanks to the organizers for a successful German-French Retreat.

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news-23795 Tue, 11 Sep 2018 10:24:16 +0200 Poster Award for Lin Yang www.cpc-researchschool.orgnews-events/news/news/article/23795/index.html Lin Yang, PhD student in Otmar Schmid's lab "Dynamics of Inflammatory Lung Diseases" at the ILBD, received the first prize in the poster session "Basic Nanomedicine" at the 11th European and Global Summit for Clinical Nanomedicine, Targeted Delivery and Precision Medicine – The Building Blocks to Personalized Medicine, which took place in Basel, Switzerland, from September 02-05, 2018 (https://www.clinam.org/). Lin presented his poster with the title "Novel imaging tools for deciphering pulmonary delivery and 3D cellular distribution of nanomaterials" in the poster session "Basic Nanomedicine" with over 110 posters in total. Congratulations, Lin!

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news-23768 Fri, 24 Aug 2018 13:09:31 +0200 Public outreach activities of the CPC Research School at "Mini-München" 2018 www.cpc-researchschool.orgnews-events/news/news/article/23768/index.html “Mini-München”, which took place in the Olympiapark from July 30 to August 17, 2018, is the biggest municipal summer holiday program for children in Munich and features a parent-free area with city-like structures, where children get employed, study at the university, make money, and shape the city in every thinkable way. Organized and supervised by PD Dr. Claudia Staab-Weijnitz, Scientific Director of the CPC Research School, Mini-München this year included an area on air and lung research, in the so-called “Forschungsstadt” at Mini-München University. For the complete three-week duration of Mini-München, we, i.e. alumni, PhD and MD students from the CPC Research School, were engaged to teach the young Mini-München scientists about lung physiology and pathology in a playful and entertaining manner. For instance, together with the young students, we carefully investigated real pig lungs and not only characterized anatomical structures like lobes, fissurae, arteriae, venae, and bronchi but also learnt about thoracic pressures, breathing physiology, and the function of mucus. It was quite impressive for the young researchers to inflate different bronchi and see the corresponding lobe getting bloated.

Since research in lung diseases is our main work at the ILBD/CPC, we also illustrated the devastating consequences of cigarette consumption, which is the most avoidable risk factor for many lung pathologies. How does it feel for a long-term smoker to climb up to the fifth floor? To comprehend the impact of cigarette smoke on our health, the young researchers did some physical exercise and afterwards tried breathing just through a drinking straw. The big effort to exhale through the straw made everyone breathe with mouth wide open after seconds already, providing everyone with a glimpse of what having COPD (chronic obstructive pulmonary disease), which is mostly caused by smoking, may feel like. Furthermore, in order to illustrate how much dirt is actually delivered to the lung by smoking a cigarette, we positioned a white cotton pad into a special chamber and “smoked” one cigarette with the help of bellows. A similar experiment was done with cotton wool in a bottle. In both experiments, the kids could clearly see how many toxic combustion residues are passing the cigarette filter which is actually made to protect smoker lungs from tar and other pathogenic substances in the cigarette. 

The last picture nicely shows how much dirt actually reaches the lungs of smokers who just want the nicotine. And keep in mind: This was just one cigarette! The kids also calculated the costs for one pack of cigarettes per day in a year. And all young and grown-up scientists agreed that one could have much more fun investing 2300 (in words: two thousand and three hundred) Euros in a nice city trip or better food or also a new mobile phone.

Our info-training lectures contributed to health education and smoking prevention and we hope that some young researcher will let their friends know that smoking is anything but cool, should the subject come up. And say “no” when being offered a smoke.

Johannes Nowak  

For more information on the Mini-München concept, also refer to http://www.mini-muenchen.info/index.php?article_id=19

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news-23767 Thu, 23 Aug 2018 10:01:00 +0200 Introductory Seminars - Fundamentals of Lung Biology and Physiology www.cpc-researchschool.orgnews-events/news/news/article/23767/index.html You are cordially invited to join the seminars "Fundamentals of Lung Biology and Physiology", which will take place from September 26-28, 2018 (CPC seminar room 2nd floor, Max-Lebsche-Platz 31).

Preliminary program

This course is mandatory for all new MD and PhD students (class 2018/19) and those who have not completed the course yet; everyone else is welcome to join.

We are looking forward to seeing you all in September.

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news-23608 Thu, 19 Jul 2018 11:22:25 +0200 German-French Retreat in Paris - Preliminary Program available www.cpc-researchschool.orgnews-events/news/news/article/23608/index.html It is our sincere pleasure to announce the next German-French Lung Retreat, which will take place in Paris right before the ERS International Congress (https://erscongress.org), on September 12 and 13, 2018. Please take a look at the program to see your session assignment.

Date: September 12-13, 2018

Location: Biopark Auditorium (11 Rue Watt, 75013 Paris)

We are looking forward to seeing you in Paris.

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news-23559 Fri, 29 Jun 2018 13:59:00 +0200 6th Munich International Autumn School 2018 - Call for Applications! www.cpc-researchschool.orgnews-events/news/news/article/23559/index.html It is our pleasure to announce the 6th Munich International Autumn School (MIAS), which will take place from November 26 to 30, 2018.

This year’s Munich International Autumn School offers a limited number of training positions to clinicians or scientists with a MD or PhD background. Please see the flyer for details.

Please send your application until July 31, 2018, including a CV and a list of publications as well as a motivation letter (1/2 page), to research-school@cpc-munich.org. Applications will be reviewed by the MIAS organizing committee. Successful applicants will be notified in due time via email. Costs for accommodation and meals are covered by the CPC Research School and AtemWeg - The Lung Disease Research Foundation, supported by an unrestricted educational grant by Boehringer Ingelheim.

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news-23541 Thu, 28 Jun 2018 12:57:09 +0200 Register now: Sequencing Spotlight on September 27 www.cpc-researchschool.orgnews-events/news/news/article/23541/index.html Learn about cutting-edge seq techniques from the experts in the local scientific community in an informal half-day symposium.

Register now!

Date: Thurs, September 27, 2018
Time: 13:00 - approx. 17:30
Venue: Biomedical Center, small lecture hall N02.040 (Martinsried Campus)
Target audience: Students, doctoral candidates and junior scientists who are interested in seq-analysis and/or being literate in seq terms, open to the whole scientific community. All are welcome!

6x 30 min talks and poster session during breaks

Preliminary program:

Welcome and introduction - Wolfgang Enard

  • Technology - Helmut Blum, LAFUGA Genomics Unit, LMU Gene Center 
  • Genome Seq - Jochen Wolf, Evolutionary Biology, LMU Biocenter
  • RNA Seq - Wolfgang Enard, Anthropology and Human Genetics, LMU Biocenter

Break and poster session

  • Chromosome Mapping - Tobias Straub, Core Facility Bioinformatics, LMU BMC
  • Case example of data analysis: Maria Colomé Tatché, Computational Epigenomics, ICB, Helmholtz Zentrum München
  • Case example of data analysis: Julien Gagneur, Computational Biology, TUM Department of Informatics
  • Closing remarks

Happy Hour and poster session/discussion

Flyer

Co-organized by the graduate programs: SFB-IRTG 1243 Cancer Evolution, SFB-IRTG 1064 Chromatin Dynamics, IMPRS-LS Max Planck Research School for Life Sciences, QBM Graduate School of Quantitative Biosciences Munich, SFB-IRTG 914 Leukocyte Trafficking, SFB-IRTG 1054 Cell-Fate Decisions in Immune Systems, LSM Graduate School of Life Science Munich, Research School Lung and Disease

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news-23523 Tue, 26 Jun 2018 11:40:17 +0200 National and international research funding opportunities for Postdocs www.cpc-researchschool.orgnews-events/news/news/article/23523/index.html Monday,  July 09, 2018, 5.15 p.m.
Topic: "National and international research funding opportunities for Postdocs"
Location: N02.017, BMC, LMU
 

The aim of this information session is to provide an overview of research funding organisations, their funding portfolio as well as basic tips for writing grant proposals. The focus lies on national and European research funding programs for the early phase of the scientific career after the PhD. All PhD students and postdocs are welcome - the main target groups are PhD students at the end of their doctorate and early Post-Docs.

Announcement

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news-23522 Tue, 26 Jun 2018 11:36:39 +0200 Summer Lectures 2018: How to discover a drug? Lessons learned. www.cpc-researchschool.orgnews-events/news/news/article/23522/index.html Let’s make a journey together into the future of drug discovery and development based on 100 years of lessons learned. What were the groundbreaking findings and which molecules really changed the world? How do drugs really work? Where are we now and what are the future challenges in the management of drug development in industry and science? These interactive lectures will highlight prominent examples from academic and industrial practice of major drug classes and breakthroughs will be used as means to explore various aspects of drug discovery and development.

You will become familiar with opportunities and challenges of drug discovery and development, from the identification of potential targets over target validation, clinical trials, regulatory approvals, and potential applications to  the market. You will get insights into industrial research and entrepreneurial thinking by discussing value chains. The lectures will also address necessity and opportunities of interdisciplinary projects for breakthroughs in drug discovery and development. As CEO of Helmholtz Center Munich and Professor at TUM, Dr. Günther Wess warmly welcomes all members of the Center and HELENA as well as TUM students to participate. After the lectures, Günther Wess would like to invite you for further discussions with drinks and snacks. The lecture on July 18 will be concluded by the event ‚Helmholtz & Music‘. 

 

10th July:  
Druggable targets and drug like molecules – part I 
Molecules that changed the world. Case studies of breakthroughs.

11th July: 
Druggable targets and drug like molecules – part II
Compound progression from bench to patient. Technologies, knowledge and criteria for decision making. How do drugs really work?

17th July: 
Drug discovery and development in the era of personalized medicine 
From hype to future medicine. New modalities of treatment that will change healthcare. A revolution?

18th July: 
The management of drug discovery and development
Decision making and value creation. Strategy, leadership, communication and teams. Career paths in academia and industry. Management of global pharma.


Each date from 4:00 – 5:30 p.m.
Neuherberg Helmholtz Campus / Building 23 / Auditorium

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news-23574 Thu, 14 Jun 2018 19:21:00 +0200 Congratulations Larissa Knüppel www.cpc-researchschool.orgnews-events/news/news/article/23574/index.html Larissa Knüppel, member of the CPC Research School and PhD student in the Core Unit Matrix Genotyping, successfully defended her PhD thesis "Function and druggability of FK506 binding proteins (FICBP's) in pulmonary fibrosis" on June 13, 2018 in Munich.

Congratulations!!!

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news-23481 Fri, 08 Jun 2018 14:44:40 +0200 PD Dr. Claudia Staab-Weijnitz invited to the editorial board of Respiratory Research www.cpc-researchschool.orgnews-events/news/news/article/23481/index.html PD Dr. Claudia Staab-Weijnitz from the Institute of Lung Biology and Disease (ILBD) and Comprehensive Pneumology Center (CPC) has been invited to join the editorial board of the journal Respiratory Research.

Respiratory Research is the leading fully open access journal in the field of respiratory medicine. The journal promotes scientific exchange by facilitating worldwide visibility of high-quality papers, reviews and commentaries on clinical and fundamental research on all aspects of respiratory medicine and related diseases. It is therefore an important resource for pulmonologists, allergists, immunologists, and other physicians, researchers, medical staff, and medical students.

Since 2017, Claudia Staab-Weijnitz is head of the Core Unit "Matrix Genotyping" at the ILBD / CPC and Scientific Director of the MD/Ph.D. program CPC Research School “Lung Biology and Disease”. In her research, she studies genetic predisposition to chronic lung disease and explores the collagen biosynthesis and maturation pathway as a novel therapeutic avenue for the treatment of lung fibrosis.

For more information, please refer to the journal’s website:
respiratory-research.biomedcentral.com

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news-23477 Thu, 07 Jun 2018 16:05:41 +0200 Save the date: Sequencing Spotlight on September 27 www.cpc-researchschool.orgnews-events/news/news/article/23477/index.html Learn about cutting-edge seq techniques from the experts in the local scientific community in an informal half-day symposium.

Details and registration coming soon!

Preliminary title: Seq Spotlight on Campus
Date: Thurs, September 27, 2018
Time: 13:00 - approx. 17:30
Venue: Biomedical Center, small lecture hall N02.040 (Martinsried Campus)
Target audience: students, doctoral candidates and junior scientists who are interested in seq-analysis and/or being literate in seq terms, open to the whole scientific community. All are welcome!

6x 30 min talks and poster session during breaks

Preliminary program:

Welcome and introduction - Wolfgang Enard

  • Technology - Helmut Blum, LAFUGA Genomics Unit, LMU Gene Center 
  • Genome Seq - Jochen Wolf, Evolutionary Biology, LMU Biocenter
  • RNA Seq - Wolfgang Enard, Anthropology and Human Genetics, LMU Biocenter

Break and poster session

  • Chromosome Mapping - Tobias Straub, Core Facility Bioinformatics, LMU BMC
  • Case example of data analysis: Maria Colomé Tatché, Computational Epigenomics, ICB, Helmholtz Zentrum München
  • Case example of data analysis: Julien Gagneur, Computational Biology, TUM Department of Informatics
  • Closing remarks

Happy Hour and poster session/discussion

 

Co-organized by the graduate programs: SFB-IRTG 1243 Cancer Evolution, SFB-IRTG 1064 Chromatin Dynamics, IMPRS-LS Max Planck Research School for Life Sciences, QBM Graduate School of Quantitative Biosciences Munich, SFB-IRTG 914 Leukocyte Trafficking, SFB-IRTG 1054 Cell-Fate Decisions in Immune Systems, LSM Graduate School of Life Science Munich, Research School Lung and Disease

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news-23440 Thu, 24 May 2018 14:44:25 +0200 German-French Retreat in Paris - Call for abstracts www.cpc-researchschool.orgnews-events/news/news/article/23440/index.html It is our sincere pleasure to announce the next German-French Lung Retreat, which will take place in Paris right before the ERS International Congress (https://erscongress.org), around September 13, 2018.

 

The one-day program consists of scientific highlight and career talks, a poster session incl. poster walks, a mentoring session, and great opportunities to network.

 

If you are interested to join us in Paris, please submit your presentation title and abstract (300 words max.) to research-school@cpc-munich.org by June 15, 2018. If your abstract is accepted, costs for travel and accomodation (two nights) will be covered.

 

Please note that we are currently waiting for the final approval of the location and the exact date (Sep 13 or 14) and will communicate this as soon as possible.

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news-23413 Tue, 08 May 2018 12:10:55 +0200 Carolina Ballester Lopez receives International Trainee Scholarship Award www.cpc-researchschool.orgnews-events/news/news/article/23413/index.html Carolina Ballester Lopez, PhD student in Ali Önder Yildirim's Lab ”Immunopathology of COPD” at the ILBD/CPC received an International Trainee Scholarship Award for 2018 from the American Thoracic Society (ATS). This award provides support to attend the ATS International Conference in San Diego, CA, and includes a one year In-Training Membership. Carolina Ballester Lopez's abstract with the title “The Novel Notch Ligand DNER Modulates IFNγ Levels in Recruited Macrophages by Enhancing Non-Canonical Notch During COPD Progression” was chosen as an oral presentation in the Mini Symposium session “Asthma and COPD – the best of respiratory structure and function”, which will take place on May 23, 2018.

Abstract  - In the last decades it has become more evident that chronic inflammation plays a pivotal role in the progression of chronic obstructive pulmonary disease (COPD). Nevertheless, the underlying pathways that drive and exacerbate the disease remain unclear. A novel non-canonical Notch ligand, DNER (Delta/Notch-like Epidermal Growth Factor (EGF)-related Receptor), has been shown in a genome-wide association study (GWAS) to correlate with GOLD stages (Hancock et al. PLoS Genet 2012). We identified that DNER expression is increased in COPD patients compared to healthy lungs and mainly localized to macrophages. In in vivo studies, immunofluorescence revealed lower nuclear translocation of NICD1 in cigarette smoke-exposed Dner-/- vs WT mice alveolar macrophages that reduces a significantly lower F4/80+ SiglecF- IFNγ+ macrophage population in cigarette smoke exposed Dner-/- mice compared to WT. Together, DNER is a novel protein induced in COPD patients and chronic CS-exposed mice that regulates IFNγ secretion via non-canonical Notch signaling in pro-inflammatory recruited macrophages. These results provide a new pathway involved in COPD immunity that could contribute to the discovery of innovative therapeutic targets.

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news-23412 Tue, 01 May 2018 11:37:00 +0200 Arunima Sengupta receives ATS Abstract Scholarship www.cpc-researchschool.orgnews-events/news/news/article/23412/index.html Arunima Sengupta, PhD student in the core unit "Live Cell Imaging" at the iLBD/CPC and directly supervised by Dr. Gerald Burgstaller, received an Abstract Scholarship for the 2018 ATS International Conference in San Diego, CA, USA. Her abstract with the title “Secreted Frizzled Related Protein 1 (SFRP1) As A Novel Regulator Of The RhoA/Rock1 Pathway Is Expressed In A Distinct Subset Of Fibroblasts In The Fibrotic Lung” was chosen by the Assembly on Respiratory Cell and Molecular Biology (RCMB). Congratulations!

 

Abstract:

The activation, invasion and differentiation of fibroblasts into myofibroblasts are hallmarks of progressing lung fibrogenesis. We present new evidence that SFRP1 is expressed in a very distinct subpopulation of fibroblasts, which are alpha-smooth muscle actin (αSMA) negative, during the onset and progression of fibrosis. Moreover, our data support SFRP1's novel role as a regulator of the ß- catenin independent Wnt pathway along the RhoA-Rock1 axis, thus altering the actin cytoskeleton and cellular morphology. Therefore, SFRP1 might stand out as a novel biomarker for early events in lung fibrosis and will be of great importance to establish new therapeutic interventions.

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news-23441 Mon, 30 Apr 2018 14:57:00 +0200 Girls’ and Boys’ Day 2018 www.cpc-researchschool.orgnews-events/news/news/article/23441/index.html Like every year, a nationwide effort is made to offer girls and also boys the possibility to get to know professional areas and jobs, which they might not typically consider after their school career. The aim and concept of the Girls’ and Boys’ Day is to broaden the participants’ horizon on career options beyond gender specific clichés. As the German Research Center for Health and Environment, the Helmholtz Center in Munich supports the endeavor to motivate young girls and boys to look beyond traditional gender-specific professions, not least, because the center itself takes much responsibility in scientific education of young researchers and gender balance.

On April 26, 2018, the Comprehensive Pneumology Center (CPC), as part of the Helmholtz Institute for Lung Biology and Disease, invited five girls and two boys from different schools in and around Munich to learn about the lung and about a scientist’s life in the field of medical sciences. After an introduction to the institute, the laboratories, and current lung research challenges, the students were encouraged to take up pipettes and plunge right into real scientific experiments. As if they were born scientists, the girls and boys isolated primary mouse lung cells for cell culture, learned about advanced in vitro cell culture techniques, and isolated DNA from vegetables and fruit.

Execution of all these experiments makes hungry! During the pizza lunch with all scientists involved, the girls and boys took their chance to ask their questions on, among others, career decisions and received advice for their own educational and professional path. Some participants even prepared questions for the organizers, which testified their interest and their active participation.

As a grand finale, and since this naturally follows a good lunch, the scientists made fresh ice-cream from blended strawberries and chocolate with the help of liquid nitrogen – very yummy! The ice-cream even attracted others from the institute passing by the corridors!

All scientists that performed the experiments that day enjoyed the time together and were happy to have been able to contribute and motivate the girls and boys for new routes in their educational and professional career. For us, it was really great to have had the girls and boys around and to have passed on some of our knowledge, particularly the fun part of our job. We were not only happy to hear that after the event most participants could imagine a career in science or field-related jobs but also that one or two took the chance to learn about their options even though they learnt that science might not be their field of choice. 

 

- Maximilian Strunz
 

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news-20029 Tue, 27 Mar 2018 11:00:00 +0200 PhD positions available - Apply now! www.cpc-researchschool.orgnews-events/news/news/article/20029/index.html The International Research School “Lung Biology and Disease“ in the field of translational pulmonary medicine is offering Full-time PhD Positions:

  

Project A: Development of in vitro approaches for research on mechanisms of lung regeneration

Supervisor: PD Dr. Claudia Staab-Weijnitz

Our knowledge about lung regeneration so far stems largely from studies in the mouse, where initial acute injury of the respiratory epithelium is induced by exposition to chemicals. These mouse models are associated with substantial distress and suffering for the animal. Furthermore, the cellular composition of the upper respiratory epithelium differs considerably between mice and men. Therefore, the objective of this Ph.D. project is to develop in vitro methods for the analysis of lung injury and regeneration in a human cell-derived organotypic system as an alternative to animal experimentation.

 

Project B: Validation of novel drug therapeutic strategies for lung fibrosis in vivo

Supervisor: PD Dr. Claudia Staab-Weijnitz

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with few treatment options and a poor prognosis. Based on in vitro experiments and patient samples, we have identified the protein FKBP10 as a promising drug target for IPF. The objective of this Ph.D. project is to devise and evaluate novel therapeutic approaches for lung fibrosis in an in vivo approach, including the use of a conditional Fkbp10 knockout system.

 

Project C: Lung bioengineering: Rebuilding lungs as a future alternative for transplantation

Supervisors: Prof. Dr. Dr. Melanie Königshoff, Dr. Gerald Burgstaller

The aim of this project is to understand how reseeded stem cells (iPS and endogenous lung progenitor cells) are behaving in a decellularized lung scaffold, how they differentiate into lung cell phenotypes and how differentiated cells find their native niche in the extracellular matrix. For that, the project makes use of human lung tissue in combination with top-notch technologies, such as material engineering, advanced live imaging (confocal, lightsheet and 2-photon), single-cell RNAseq, and proteomic approaches.

 

Project D: Aging alveolar epithelial cells and their contribution to lung disease

Supervisors: Prof. Dr. Dr. Melanie Königshoff, Dr. Mareike Lehmann

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with only limited treatment options. The incidence of IPF increases with age and accumulating evidence strongly suggests aging as a crucial driver of IPF. Alveolar epithelial cells are important cells for lung function and their dysfunction has been proposed as one driver of  IPF development. This project aims to investigate the aged alveolar epithelial cells and their contribution to disease development. Primary mouse and human alveolar epithelial cell isolations, molecular biology, single-cell RNA seq, and preclinical ex vivo models will be used to determine the phenotypes of aged epithelial cells.

 

Project E: Virus infections as risk factors in the development of bronchopulmonary dysplasia (BPD)

Supervisor: Prof. Dr. Heiko Adler

Neonatal chronic lung disease (nCLD), also known as BPD, is the most common complication in preterm infants and has long‐term health consequences. In this project, we use new in vitro and pre-clinical in vivo models to investigate how viral infections determine the development of BPD in short and long-term studies.

 

Project F: Nanotoxicology in human bronchial epithelial cells

Supervisors: PD Dr. Anne Hilgendorff, Dr. Tobias Stöger

Understanding the interaction of inhaled nanomaterials with the respiratory system and individuals with chronic/inflammatory lung disease is critical to prevent or treat exposure related health effects in the future. We will utilize human cell-based assays to determine nanoparticle-induced immunomodulatory effects in primary epithelial cells from healthy and COPD patients. Cells will be exposed to engineered and environmental nanoparticles in an established realistic air liquid interface cell exposure system and particle-induced immunostimulation will be monitored at the cellular and molecular level. Data from patients and epidemiological cohorts will be used to translate findings into subjects exposed to air pollution in daily life.

 

Project G: Regulation of proteasome activators in lung biology and disease

Supervisor: Prof. Dr. Silke Meiners

Regulation of proteasome function via proteasome regulators emerges as a new concept in cell biology and disease. The cellular function of this super-complex formation is not understood. The objective of this Ph.D project is to develop reporter cells and mice to monitor endogenous regulation of the proteasome activator PA200 in the cell and its dysregulation in lung diseases using CRIPSR/Cas-mediated engineering and Fret-based technologies.

 

The program is highly selective and invites applicants with a master's degree (or equivalent) in any field of the life sciences or medicine to commit to a career in translational medical research.

If you are interested in a doctoral position at the CPC, we invite you to send us your application, including the following documents (as a single pdf file):

  • CV (max. 2 pages, in English)
  • Motivation letter (in English, approximately one page) indicating your particular qualification and motivation for MD, MD/PhD or PhD studies and summarizing your research interests, ideas, and expectations regarding your future professional career.
  • Proof of a master's degree or a first professional qualification degree from a university. German applicants - or foreign applicants who studied at German universities - without a master's degree, have to provide evidence of completion of a Diploma or "Staatsexamen" in the above-mentioned disciplines.
  • Two letters of recommendation from instructors, advisors, or any other person qualified to evaluate your academic performance and potential for graduate training.
  • Information or certificates about English language skills, if your mother tongue is not English. Good knowledge of the English language is necessary for successful completion of the program. Desirable is: a) An internationally recognized examination in English, b) a degree of an English-speaking school or university, or c) a longer stay abroad. 

 

Closing date: May 15, 2018

 

 

Please contact Dr. Doreen Franke (research-school@cpc-munich.org) if you have any questions.

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news-20026 Mon, 26 Mar 2018 11:31:00 +0200 DZL Mentoring Program – Call for Applications www.cpc-researchschool.orgnews-events/news/news/article/20026/index.html The German Center for Lung Research (DZL) aims to support highly motivated young DZL members working in biomedical sciences/medicine in their career development. Thereby, the DZL seeks to identify and raise future DZL (and lung community) leaders for executive-level positions requiring management and leadership skills.

The DZL Mentoring program fosters establishing a network of early career scientists and clinicians who are interested in and committed to engaging in mentor-mentee relationships. Primary target group includes clinical fellows, post-doctoral fellows, and junior PIs early in their career development.

Framework

  • Individual mentor-mentee partnerships
  • Regular individual mentor-mentee meetings
  • Establishment of a strong contact and peer network within the DZL and beyond
  • Leadership-, Management- and Soft Skill Courses/Workshops (building upon site infrastructure, linking with other programs and initiatives)

The following documents are required for the application process:

  • Motivation letter/Statement of interest
  • Current CV
  • Completed questionnaire

Please contact academynoSp@m@dzl.de for further information or if you have any questions.

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news-20036 Fri, 23 Mar 2018 13:59:00 +0100 Munich International Autumn School 2018 - Save the date! www.cpc-researchschool.orgnews-events/news/news/article/20036/index.html It is our pleasure to announce the 6th Munich International Autumn School (MIAS), which will take place from November 26 to 30, 2018. Stay tuned for details!

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Wissenschaft & Zentrum
news-19781 Tue, 20 Mar 2018 11:43:00 +0100 Munich Lung Conference 2018: Register now! www.cpc-researchschool.orgnews-events/news/news/article/19781/index.html Register now for the Munich Lung Conference 2018 / International DZL Symposium.

Dedicated to the topic of 'Lung disease exacerbation' we are happy to have recruited very well renowned speakers from different fields for the event. Program

Details and registration: https://mlc2018.helmholtz-muenchen.de

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news-20013 Mon, 19 Mar 2018 11:44:00 +0100 Anne Sophie Lamort receives Distinguished Poster Award at the 16th Lung Science Conference in Estoril, Lisbon www.cpc-researchschool.orgnews-events/news/news/article/20013/index.html Anne Sophie Lamort, postdoctoral fellow in the Lab “Molecular Lung Carcinogenesis” of Dr. Georgios Stathopoulos at the Comprehensive Pneumology Center received a poster prize at the 16th Lung Science Conference. The title of her poster is: “Tumor-derived granulocyte chemotactic protein 2 cooperates with neutrophil proteinase 3 to drive lung adenocarcinoma. 

Inflammatory signaling from tumor to host cells is critically involved in the pathogenesis of lung adenocarcinoma (LADC), but the exact mechanisms by which the lung epithelium interacts with the immune system during carcinogenesis are obscure. We [A.S. Lamort and G. Stathopoulos] discovered that tumor-originated CXC chemokine granulocyte chemotactic protein 2 (GCP2) cooperates with neutrophil chemokines to drive LADC, providing a paradigm of how the respiratory epithelium coopts the innate immune system during carcinogenesis” summarizes Anne Sophie Lamort.

The 16th Lung Science Conference is organized by European Respiratory Society (ERS) and took place from March 08 - 11, 2018 at the Hotel Palacio Estoril, Portugal. This conference is at the forefront of basic and translational respiratory science and is an essential event for respiratory researchers looking to boost their career. It offers a unique opportunity to network with peers from across the globe and features cutting-edge abstracts on novel experimental lung research. For further information, please visit https://www.ersnet.org/congress-and-events/cell-matrix-interactions-in-lung-disease-and-regeneration

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Termine CPC Research School In den Medien Termine Intern (Intranet) - Startseite
news-19929 Mon, 05 Mar 2018 19:21:00 +0100 Congratulations Vanessa Welk www.cpc-researchschool.orgnews-events/news/news/article/19929/index.html Vanessa Welk, member of the CPC Research School and PhD student in the Research Group Proteasome Function in Lung Disease, successfully defended her PhD thesis "Dissecting the role of proteasome activators in lung biology and disease" on March 02, 2018 in Munich.

Congratulations!!!

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Termine CPC Research School Campusleben In den Medien
news-19329 Fri, 02 Mar 2018 11:20:00 +0100 MSc Project available - Research Group Systems Medicine of Chronic Lung Disease www.cpc-researchschool.orgnews-events/news/news/article/19329/index.html MSc project available in Herbert Schiller's lab!

We are looking for open minded, highly motivated individuals who are interested in understanding fundamental molecular and cellular principles of organ regeneration and fibrosis. The position will be funded with a competitive salary.

For more information, please directly contact Dr. Herbert Schiller (herbert.schiller@helmholtz-muenchen.de).

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news-19899 Tue, 20 Feb 2018 15:28:00 +0100 Congratulations Stephan Klee www.cpc-researchschool.orgnews-events/news/news/article/19899/index.html Stephan Klee, member of the CPC Research School and Munich Medical Research School, and PhD student in the Research Unit Lung Repair and Regeneration, successfully defended his PhD thesis "Matricellular Proteins in Pulmonary Fibrosis" on February 19, 2018 in Munich.

Congratulations!!!

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news-19890 Tue, 20 Feb 2018 11:38:00 +0100 Laura Klotz receives DZL Poster Award - Disease Area Lung Cancer www.cpc-researchschool.orgnews-events/news/news/article/19890/index.html Dr. Laura Klotz, physician-scientist in the lab "Molecular Lung Carcinogenesis" (headed by Dr. Georgios Stathopoulos) at the iLBD/CPC, received an award for the best poster of the disease area "Lung Cancer" at the 7th DZL Annual Meeting, held in Bad Nauheim, Germany, on February 8 and 9, 2018.

Laura Klotz presented a poster with the title "Comprehensive clinical profiling of the Gauting locoregional lung adenocarcinoma donors". Within the scope of the work, 50 different parameters of patients with loco-regional lung adenocarcinoma were examined. Lung adenocarcinoma, a special form of lung cancer, has been increasingly present in recent years in younger patients, women, and especially non-smokers, so that accurate characterization of this disease is of great importance to establish new therapeutic options. 

The German Center for Lung Research (DZL) is an association of the leading university and non-university institutions dedicated to lung research in Germany. Using translational research methods, the DZL seeks to jointly develop new approaches for the prevention, diagnosis, and therapy of serious lung diseases including asthma, chronic obstructive pulmonary disease, cystic fibrosis, diffuse parenchymal lung disease, end stage lung disease, lung cancer, pulmonary hypertension, pneumonia, and acute lung injury. Further information: www.dzl.de

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news-19889 Tue, 20 Feb 2018 11:25:00 +0100 Arunima Sengupta receives DZL Poster Award - Platform Imaging www.cpc-researchschool.orgnews-events/news/news/article/19889/index.html Arunima Sengupta, PhD student in the core unit "Live Cell Imaging" at the iLBD/CPC and directly supervised by Dr. Gerald Burgstaller, received an award for the best poster of the platform imaging (PLI) at the 7th DZL Annual Meeting, held in Bad Nauheim, Germany, on February 8 and 9, 2018. Arunima Sengupta and Dr. Gerald Burgstaller presented a poster with the title "High-resolution spatial mapping of cellular locations and interactions in a 3D ex-vivo early fibrosis model". By applying high-resolution confocal laser-scanning microscopy on 300 µm thick precision-cut lung slices (PCLS), which provide an arising and exciting new 3D cell culture technology, they were able to image an entire 300 µm-thick 3D volume comprising multiple layers of entire alveoli, bronchioles and interstitial space in unprecedented detail. In the future, they hope to use this exciting 3D ex-vivo model in combination with state-of-the-art microscopy (lightsheet and 2-photon), to study the dynamics and interaction of lung cells in early fibrotic events in real time.

The German Center for Lung Research (DZL) is an association of the leading university and non-university institutions dedicated to lung research in Germany. Using translational research methods, the DZL seeks to jointly develop new approaches for the prevention, diagnosis, and therapy of serious lung diseases including asthma, chronic obstructive pulmonary disease, cystic fibrosis, diffuse parenchymal lung disease, end stage lung disease, lung cancer, pulmonary hypertension, pneumonia, and acute lung injury. Further information: www.dzl.de

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news-20025 Tue, 16 Jan 2018 15:06:00 +0100 Munich Lung Conference 2018: Submit your abstract and register! www.cpc-researchschool.orgnews-events/news/news/article/20025/index.html It is our pleasure to announce the 2018 Munich Lung Conference (MLC).

Dedicated to the topic of 'Lung disease exacerbation' we are happy to have recruited very well renowned speakers from different fields for the event. Program

Details and registration: https://mlc2018.helmholtz-muenchen.de

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