News Feed www.cpc-researchschool.org News via RSS de www.cpc-researchschool.org Thu, 24 May 2018 19:16:51 +0200 Thu, 24 May 2018 19:16:51 +0200 TYPO3 EXT:news news-23440 Thu, 24 May 2018 14:44:25 +0200 German-French Retreat in Paris - Call for abstracts www.cpc-researchschool.orgnews-events/news/news/article/23440/index.html It is our sincere pleasure to announce the next German-French Lung Retreat, which will take place in Paris right before the ERS International Congress (https://erscongress.org), around September 13, 2018.

 

The one-day program consists of scientific highlight and career talks, a poster session incl. poster walks, a mentoring session, and great opportunities to network.

 

If you are interested to join us in Paris, please submit your presentation title and abstract (300 words max.) to research-school@cpc-munich.org by June 15, 2018. If your abstract is accepted, costs for travel and accomodation (two nights) will be covered.

 

Please note that we are currently waiting for the final approval of the location and the exact date (Sep 13 or 14) and will communicate this as soon as possible.

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news-23413 Tue, 08 May 2018 12:10:55 +0200 Carolina Ballester Lopez receives International Trainee Scholarship Award www.cpc-researchschool.orgnews-events/news/news/article/23413/index.html Carolina Ballester Lopez, PhD student in Ali Önder Yildirim's Lab ”Immunopathology of COPD” at the ILBD/CPC received an International Trainee Scholarship Award for 2018 from the American Thoracic Society (ATS). This award provides support to attend the ATS International Conference in San Diego, CA, and includes a one year In-Training Membership. Carolina Ballester Lopez's abstract with the title “The Novel Notch Ligand DNER Modulates IFNγ Levels in Recruited Macrophages by Enhancing Non-Canonical Notch During COPD Progression” was chosen as an oral presentation in the Mini Symposium session “Asthma and COPD – the best of respiratory structure and function”, which will take place on May 23, 2018.

Abstract  - In the last decades it has become more evident that chronic inflammation plays a pivotal role in the progression of chronic obstructive pulmonary disease (COPD). Nevertheless, the underlying pathways that drive and exacerbate the disease remain unclear. A novel non-canonical Notch ligand, DNER (Delta/Notch-like Epidermal Growth Factor (EGF)-related Receptor), has been shown in a genome-wide association study (GWAS) to correlate with GOLD stages (Hancock et al. PLoS Genet 2012). We identified that DNER expression is increased in COPD patients compared to healthy lungs and mainly localized to macrophages. In in vivo studies, immunofluorescence revealed lower nuclear translocation of NICD1 in cigarette smoke-exposed Dner-/- vs WT mice alveolar macrophages that reduces a significantly lower F4/80+ SiglecF- IFNγ+ macrophage population in cigarette smoke exposed Dner-/- mice compared to WT. Together, DNER is a novel protein induced in COPD patients and chronic CS-exposed mice that regulates IFNγ secretion via non-canonical Notch signaling in pro-inflammatory recruited macrophages. These results provide a new pathway involved in COPD immunity that could contribute to the discovery of innovative therapeutic targets.

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news-23412 Tue, 01 May 2018 11:37:00 +0200 Arunima Sengupta receives ATS Abstract Scholarship www.cpc-researchschool.orgnews-events/news/news/article/23412/index.html Arunima Sengupta, PhD student in the core unit "Live Cell Imaging" at the iLBD/CPC and directly supervised by Dr. Gerald Burgstaller, received an Abstract Scholarship for the 2018 ATS International Conference in San Diego, CA, USA. Her abstract with the title “Secreted Frizzled Related Protein 1 (SFRP1) As A Novel Regulator Of The RhoA/Rock1 Pathway Is Expressed In A Distinct Subset Of Fibroblasts In The Fibrotic Lung” was chosen by the Assembly on Respiratory Cell and Molecular Biology (RCMB). Congratulations!

 

Abstract:

The activation, invasion and differentiation of fibroblasts into myofibroblasts are hallmarks of progressing lung fibrogenesis. We present new evidence that SFRP1 is expressed in a very distinct subpopulation of fibroblasts, which are alpha-smooth muscle actin (αSMA) negative, during the onset and progression of fibrosis. Moreover, our data support SFRP1's novel role as a regulator of the ß- catenin independent Wnt pathway along the RhoA-Rock1 axis, thus altering the actin cytoskeleton and cellular morphology. Therefore, SFRP1 might stand out as a novel biomarker for early events in lung fibrosis and will be of great importance to establish new therapeutic interventions.

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news-23441 Mon, 30 Apr 2018 14:57:00 +0200 Girls’ and Boys’ Day 2018 www.cpc-researchschool.orgnews-events/news/news/article/23441/index.html Like every year, a nationwide effort is made to offer girls and also boys the possibility to get to know professional areas and jobs, which they might not typically consider after their school career. The aim and concept of the Girls’ and Boys’ Day is to broaden the participants’ horizon on career options beyond gender specific clichés. As the German Research Center for Health and Environment, the Helmholtz Center in Munich supports the endeavor to motivate young girls and boys to look beyond traditional gender-specific professions, not least, because the center itself takes much responsibility in scientific education of young researchers and gender balance.

On April 26, 2018, the Comprehensive Pneumology Center (CPC), as part of the Helmholtz Institute for Lung Biology and Disease, invited five girls and two boys from different schools in and around Munich to learn about the lung and about a scientist’s life in the field of medical sciences. After an introduction to the institute, the laboratories, and current lung research challenges, the students were encouraged to take up pipettes and plunge right into real scientific experiments. As if they were born scientists, the girls and boys isolated primary mouse lung cells for cell culture, learned about advanced in vitro cell culture techniques, and isolated DNA from vegetables and fruit.

Execution of all these experiments makes hungry! During the pizza lunch with all scientists involved, the girls and boys took their chance to ask their questions on, among others, career decisions and received advice for their own educational and professional path. Some participants even prepared questions for the organizers, which testified their interest and their active participation.

As a grand finale, and since this naturally follows a good lunch, the scientists made fresh ice-cream from blended strawberries and chocolate with the help of liquid nitrogen – very yummy! The ice-cream even attracted others from the institute passing by the corridors!

All scientists that performed the experiments that day enjoyed the time together and were happy to have been able to contribute and motivate the girls and boys for new routes in their educational and professional career. For us, it was really great to have had the girls and boys around and to have passed on some of our knowledge, particularly the fun part of our job. We were not only happy to hear that after the event most participants could imagine a career in science or field-related jobs but also that one or two took the chance to learn about their options even though they learnt that science might not be their field of choice. 

 

- Maximilian Strunz
 

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news-20029 Tue, 27 Mar 2018 11:00:00 +0200 PhD positions available - Apply now! www.cpc-researchschool.orgnews-events/news/news/article/20029/index.html The International Research School “Lung Biology and Disease“ in the field of translational pulmonary medicine is offering Full-time PhD Positions:

  

Project A: Development of in vitro approaches for research on mechanisms of lung regeneration

Supervisor: PD Dr. Claudia Staab-Weijnitz

Our knowledge about lung regeneration so far stems largely from studies in the mouse, where initial acute injury of the respiratory epithelium is induced by exposition to chemicals. These mouse models are associated with substantial distress and suffering for the animal. Furthermore, the cellular composition of the upper respiratory epithelium differs considerably between mice and men. Therefore, the objective of this Ph.D. project is to develop in vitro methods for the analysis of lung injury and regeneration in a human cell-derived organotypic system as an alternative to animal experimentation.

 

Project B: Validation of novel drug therapeutic strategies for lung fibrosis in vivo

Supervisor: PD Dr. Claudia Staab-Weijnitz

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with few treatment options and a poor prognosis. Based on in vitro experiments and patient samples, we have identified the protein FKBP10 as a promising drug target for IPF. The objective of this Ph.D. project is to devise and evaluate novel therapeutic approaches for lung fibrosis in an in vivo approach, including the use of a conditional Fkbp10 knockout system.

 

Project C: Lung bioengineering: Rebuilding lungs as a future alternative for transplantation

Supervisors: Prof. Dr. Dr. Melanie Königshoff, Dr. Gerald Burgstaller

The aim of this project is to understand how reseeded stem cells (iPS and endogenous lung progenitor cells) are behaving in a decellularized lung scaffold, how they differentiate into lung cell phenotypes and how differentiated cells find their native niche in the extracellular matrix. For that, the project makes use of human lung tissue in combination with top-notch technologies, such as material engineering, advanced live imaging (confocal, lightsheet and 2-photon), single-cell RNAseq, and proteomic approaches.

 

Project D: Aging alveolar epithelial cells and their contribution to lung disease

Supervisors: Prof. Dr. Dr. Melanie Königshoff, Dr. Mareike Lehmann

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with only limited treatment options. The incidence of IPF increases with age and accumulating evidence strongly suggests aging as a crucial driver of IPF. Alveolar epithelial cells are important cells for lung function and their dysfunction has been proposed as one driver of  IPF development. This project aims to investigate the aged alveolar epithelial cells and their contribution to disease development. Primary mouse and human alveolar epithelial cell isolations, molecular biology, single-cell RNA seq, and preclinical ex vivo models will be used to determine the phenotypes of aged epithelial cells.

 

Project E: Virus infections as risk factors in the development of bronchopulmonary dysplasia (BPD)

Supervisor: Prof. Dr. Heiko Adler

Neonatal chronic lung disease (nCLD), also known as BPD, is the most common complication in preterm infants and has long‐term health consequences. In this project, we use new in vitro and pre-clinical in vivo models to investigate how viral infections determine the development of BPD in short and long-term studies.

 

Project F: Nanotoxicology in human bronchial epithelial cells

Supervisors: PD Dr. Anne Hilgendorff, Dr. Tobias Stöger

Understanding the interaction of inhaled nanomaterials with the respiratory system and individuals with chronic/inflammatory lung disease is critical to prevent or treat exposure related health effects in the future. We will utilize human cell-based assays to determine nanoparticle-induced immunomodulatory effects in primary epithelial cells from healthy and COPD patients. Cells will be exposed to engineered and environmental nanoparticles in an established realistic air liquid interface cell exposure system and particle-induced immunostimulation will be monitored at the cellular and molecular level. Data from patients and epidemiological cohorts will be used to translate findings into subjects exposed to air pollution in daily life.

 

Project G: Regulation of proteasome activators in lung biology and disease

Supervisor: Prof. Dr. Silke Meiners

Regulation of proteasome function via proteasome regulators emerges as a new concept in cell biology and disease. The cellular function of this super-complex formation is not understood. The objective of this Ph.D project is to develop reporter cells and mice to monitor endogenous regulation of the proteasome activator PA200 in the cell and its dysregulation in lung diseases using CRIPSR/Cas-mediated engineering and Fret-based technologies.

 

The program is highly selective and invites applicants with a master's degree (or equivalent) in any field of the life sciences or medicine to commit to a career in translational medical research.

If you are interested in a doctoral position at the CPC, we invite you to send us your application, including the following documents (as a single pdf file):

  • CV (max. 2 pages, in English)
  • Motivation letter (in English, approximately one page) indicating your particular qualification and motivation for MD, MD/PhD or PhD studies and summarizing your research interests, ideas, and expectations regarding your future professional career.
  • Proof of a master's degree or a first professional qualification degree from a university. German applicants - or foreign applicants who studied at German universities - without a master's degree, have to provide evidence of completion of a Diploma or "Staatsexamen" in the above-mentioned disciplines.
  • Two letters of recommendation from instructors, advisors, or any other person qualified to evaluate your academic performance and potential for graduate training.
  • Information or certificates about English language skills, if your mother tongue is not English. Good knowledge of the English language is necessary for successful completion of the program. Desirable is: a) An internationally recognized examination in English, b) a degree of an English-speaking school or university, or c) a longer stay abroad. 

 

Closing date: May 15, 2018

 

 

Please contact Dr. Doreen Franke (research-school@cpc-munich.org) if you have any questions.

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news-20026 Mon, 26 Mar 2018 11:31:00 +0200 DZL Mentoring Program – Call for Applications www.cpc-researchschool.orgnews-events/news/news/article/20026/index.html The German Center for Lung Research (DZL) aims to support highly motivated young DZL members working in biomedical sciences/medicine in their career development. Thereby, the DZL seeks to identify and raise future DZL (and lung community) leaders for executive-level positions requiring management and leadership skills.

The DZL Mentoring program fosters establishing a network of early career scientists and clinicians who are interested in and committed to engaging in mentor-mentee relationships. Primary target group includes clinical fellows, post-doctoral fellows, and junior PIs early in their career development.

Framework

  • Individual mentor-mentee partnerships
  • Regular individual mentor-mentee meetings
  • Establishment of a strong contact and peer network within the DZL and beyond
  • Leadership-, Management- and Soft Skill Courses/Workshops (building upon site infrastructure, linking with other programs and initiatives)

The following documents are required for the application process:

  • Motivation letter/Statement of interest
  • Current CV
  • Completed questionnaire

Please contact academynoSp@m@dzl.de for further information or if you have any questions.

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news-20036 Fri, 23 Mar 2018 13:59:00 +0100 Munich International Autumn School 2018 - Save the date! www.cpc-researchschool.orgnews-events/news/news/article/20036/index.html It is our pleasure to announce the 6th Munich International Autumn School (MIAS), which will take place from November 26 to 30, 2018. Stay tuned for details!

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news-19781 Tue, 20 Mar 2018 11:43:00 +0100 Munich Lung Conference 2018: Register now! www.cpc-researchschool.orgnews-events/news/news/article/19781/index.html Register now for the Munich Lung Conference 2018 / International DZL Symposium.

Dedicated to the topic of 'Lung disease exacerbation' we are happy to have recruited very well renowned speakers from different fields for the event. Program

Details and registration: https://mlc2018.helmholtz-muenchen.de

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news-20013 Mon, 19 Mar 2018 11:44:00 +0100 Anne Sophie Lamort receives Distinguished Poster Award at the 16th Lung Science Conference in Estoril, Lisbon www.cpc-researchschool.orgnews-events/news/news/article/20013/index.html Anne Sophie Lamort, postdoctoral fellow in the Lab “Molecular Lung Carcinogenesis” of Dr. Georgios Stathopoulos at the Comprehensive Pneumology Center received a poster prize at the 16th Lung Science Conference. The title of her poster is: “Tumor-derived granulocyte chemotactic protein 2 cooperates with neutrophil proteinase 3 to drive lung adenocarcinoma. 

Inflammatory signaling from tumor to host cells is critically involved in the pathogenesis of lung adenocarcinoma (LADC), but the exact mechanisms by which the lung epithelium interacts with the immune system during carcinogenesis are obscure. We [A.S. Lamort and G. Stathopoulos] discovered that tumor-originated CXC chemokine granulocyte chemotactic protein 2 (GCP2) cooperates with neutrophil chemokines to drive LADC, providing a paradigm of how the respiratory epithelium coopts the innate immune system during carcinogenesis” summarizes Anne Sophie Lamort.

The 16th Lung Science Conference is organized by European Respiratory Society (ERS) and took place from March 08 - 11, 2018 at the Hotel Palacio Estoril, Portugal. This conference is at the forefront of basic and translational respiratory science and is an essential event for respiratory researchers looking to boost their career. It offers a unique opportunity to network with peers from across the globe and features cutting-edge abstracts on novel experimental lung research. For further information, please visit https://www.ersnet.org/congress-and-events/cell-matrix-interactions-in-lung-disease-and-regeneration

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news-19929 Mon, 05 Mar 2018 19:21:00 +0100 Congratulations Vanessa Welk www.cpc-researchschool.orgnews-events/news/news/article/19929/index.html Vanessa Welk, member of the CPC Research School and PhD student in the Research Group Proteasome Function in Lung Disease, successfully defended her PhD thesis "Dissecting the role of proteasome activators in lung biology and disease" on March 02, 2018 in Munich.

Congratulations!!!

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news-19329 Fri, 02 Mar 2018 11:20:00 +0100 MSc Project available - Research Group Systems Medicine of Chronic Lung Disease www.cpc-researchschool.orgnews-events/news/news/article/19329/index.html MSc project available in Herbert Schiller's lab!

We are looking for open minded, highly motivated individuals who are interested in understanding fundamental molecular and cellular principles of organ regeneration and fibrosis. The position will be funded with a competitive salary.

For more information, please directly contact Dr. Herbert Schiller (herbert.schiller@helmholtz-muenchen.de).

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news-19899 Tue, 20 Feb 2018 15:28:00 +0100 Congratulations Stephan Klee www.cpc-researchschool.orgnews-events/news/news/article/19899/index.html Stephan Klee, member of the CPC Research School and Munich Medical Research School, and PhD student in the Research Unit Lung Repair and Regeneration, successfully defended his PhD thesis "Matricellular Proteins in Pulmonary Fibrosis" on February 19, 2018 in Munich.

Congratulations!!!

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news-19890 Tue, 20 Feb 2018 11:38:00 +0100 Laura Klotz receives DZL Poster Award - Disease Area Lung Cancer www.cpc-researchschool.orgnews-events/news/news/article/19890/index.html Dr. Laura Klotz, physician-scientist in the lab "Molecular Lung Carcinogenesis" (headed by Dr. Georgios Stathopoulos) at the iLBD/CPC, received an award for the best poster of the disease area "Lung Cancer" at the 7th DZL Annual Meeting, held in Bad Nauheim, Germany, on February 8 and 9, 2018.

Laura Klotz presented a poster with the title "Comprehensive clinical profiling of the Gauting locoregional lung adenocarcinoma donors". Within the scope of the work, 50 different parameters of patients with loco-regional lung adenocarcinoma were examined. Lung adenocarcinoma, a special form of lung cancer, has been increasingly present in recent years in younger patients, women, and especially non-smokers, so that accurate characterization of this disease is of great importance to establish new therapeutic options. 

The German Center for Lung Research (DZL) is an association of the leading university and non-university institutions dedicated to lung research in Germany. Using translational research methods, the DZL seeks to jointly develop new approaches for the prevention, diagnosis, and therapy of serious lung diseases including asthma, chronic obstructive pulmonary disease, cystic fibrosis, diffuse parenchymal lung disease, end stage lung disease, lung cancer, pulmonary hypertension, pneumonia, and acute lung injury. Further information: www.dzl.de

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news-19889 Tue, 20 Feb 2018 11:25:00 +0100 Arunima Sengupta receives DZL Poster Award - Platform Imaging www.cpc-researchschool.orgnews-events/news/news/article/19889/index.html Arunima Sengupta, PhD student in the core unit "Live Cell Imaging" at the iLBD/CPC and directly supervised by Dr. Gerald Burgstaller, received an award for the best poster of the platform imaging (PLI) at the 7th DZL Annual Meeting, held in Bad Nauheim, Germany, on February 8 and 9, 2018. Arunima Sengupta and Dr. Gerald Burgstaller presented a poster with the title "High-resolution spatial mapping of cellular locations and interactions in a 3D ex-vivo early fibrosis model". By applying high-resolution confocal laser-scanning microscopy on 300 µm thick precision-cut lung slices (PCLS), which provide an arising and exciting new 3D cell culture technology, they were able to image an entire 300 µm-thick 3D volume comprising multiple layers of entire alveoli, bronchioles and interstitial space in unprecedented detail. In the future, they hope to use this exciting 3D ex-vivo model in combination with state-of-the-art microscopy (lightsheet and 2-photon), to study the dynamics and interaction of lung cells in early fibrotic events in real time.

The German Center for Lung Research (DZL) is an association of the leading university and non-university institutions dedicated to lung research in Germany. Using translational research methods, the DZL seeks to jointly develop new approaches for the prevention, diagnosis, and therapy of serious lung diseases including asthma, chronic obstructive pulmonary disease, cystic fibrosis, diffuse parenchymal lung disease, end stage lung disease, lung cancer, pulmonary hypertension, pneumonia, and acute lung injury. Further information: www.dzl.de

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news-20025 Tue, 16 Jan 2018 15:06:00 +0100 Munich Lung Conference 2018: Submit your abstract and register! (copy 1) www.cpc-researchschool.orgnews-events/news/news/article/20025/index.html It is our pleasure to announce the 2018 Munich Lung Conference (MLC).

Dedicated to the topic of 'Lung disease exacerbation' we are happy to have recruited very well renowned speakers from different fields for the event. Program

Details and registration: https://mlc2018.helmholtz-muenchen.de

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news-19684 Wed, 20 Dec 2017 11:21:00 +0100 Season Greetings www.cpc-researchschool.orgnews-events/news/news/article/19684/index.html It's been a fantastic and eventful year! We would like to thank everyone contributing to our program, for supporting and shaping it, and for making progress possible.

We wish you a Happy Holiday Season and a New Year filled with health, happiness, and success! May beautiful moments and happy memories surround you with joy this Christmas and always.

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news-19683 Wed, 20 Dec 2017 10:01:00 +0100 Introductory Seminars - Fundamentals of Lung Biology and Physiology www.cpc-researchschool.orgnews-events/news/news/article/19683/index.html You are cordially invited to join the seminars "Fundamentals of Lung Biology and Physiology", which will take place from January 15-17, 2018 (CPC seminar room 2nd floor, Max-Lebsche-Platz 31).

Preliminary program

This course is mandatory for all new MD and PhD students (class 2017/18) and those who have not completed the course yet; everyone else is welcome to join.

We are looking forward to seeing you all in January.

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news-19564 Tue, 19 Dec 2017 11:13:00 +0100 Research Fellowship for Medical Student Michael Gerckens www.cpc-researchschool.orgnews-events/news/news/article/19564/index.html The CPC Research School awards a research fellowship to Michael Gerckens, an MD student under the direct supervision of Dr. Gerald Burgstaller (Core Unit "Live Cell Imaging"). Michael has joined the CPC already in 2014 as a student trainee and entered the CPC Research School program in 2016 when starting his medical thesis on "Pharmacological inhibition of the deposition of extracellular matrix proteins in chronic lung diseases by a high-throughput imaging assay". He received not only top scores in both exams of the CPC Research School, but also submitted two independent grant applications to the CPC Research School grant challenges (CPC Tandem Grant Writing Challenge, CPC Research School Grant Writing Challenge), which both got funded after internal and external review. In order to enable him to drive his research interests forward in the future, alongside his studies, the CPC Research School awards him with a research fellowship, in form of a student assistant contract, for 2018. Congratulations!

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news-19686 Wed, 13 Dec 2017 11:51:00 +0100 Congratulations Wiola Skronska-Wasek! www.cpc-researchschool.orgnews-events/news/news/article/19686/index.html Wioletta Skronska-Wasek, member of the CPC Research School and Munich Medical Research School, and PhD student in the Research Unit Lung Repair and Regeneration, successfully defended her PhD thesis "Wnt/Frizzled signaling in COPD and emphysema" on December 13, 2017 in Munich.

Congratulations!!!

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news-19682 Mon, 11 Dec 2017 13:48:00 +0100 Munich International Autumn School for Respiratory Medicine 2017 www.cpc-researchschool.orgnews-events/news/news/article/19682/index.html From December 04-08, 2017, the Munich International Autumn School (short: MIAS) was held for the fifth time at the Comprehensive Pneumology Center (CPC). Organized by the CPC Research School and greatly supported by AtemWeg - The Lung Disease Research Foundation, as well as by an unrestricted educational grant by Boehringer Ingelheim, participants learned about recent advancements in respiratory science in form of outstanding lectures by experts in the field, hands-on practical sessions in laboratories, and interactive activities to get both theoretical and practical questions answered that may promote the participant’s own research interests.

The MIAS curriculum was composed of lectures held by experts in the respiratory field and practical training modules, including the work with primary cells, cell culture, screening assays, flow cytometry and FACS, as well as lung bioengineering, and 3D live cell and tissue imaging. The program was complemented by clinical on-site visits at the Hospital of the Ludwig-Maximilians-University Munich, the Asklepios Pulmonary Hospital Munich-Gauting, and the outpatient unit to provide insights into practiced lung medicine.

Being multi-interdisciplinary within the respiratory field, 16 young scientists and clinicians with a PhD or MD background were invited to join the event, coming from all over the world, e.g. the US, Brazil, Venezuela, Armenia, Belgium, Germany, etc. They all showed a strong interest in the content of the lectures and practical assignments and interacted quite strongly with each other and both the speakers and instructors of the courses. Small groups of 5-6 participants each allowed enough room for everyone to get specific input for their own research projects. Starting from the welcome event, first contacts were exchanged and research ideas discussed. Lunch breaks were continuously used to mingle and exchange ideas and to get to know each other better. All participants took the chance to network, also during the MIAS dinner event – yet another highlight of the week, allowing room for more questions and interaction but also for fun times within the group, especially on the dancefloor.

In addition to the MIAS curriculum, the participants had the opportunity to attend the CPC Research School Career Day, an annual event that is organized by senior PhD students. While it was possibly of more benefit to the people who study and live here in Munich, many of our guests were also interested to learn about career opportunities and company profiles in the Munich area. Some speakers gave valuable insights on career development and planning, which was an additional benefit to the attendees.

We would like to thank all attendees and helpers for making this event again another highlight of the year. 

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news-19687 Fri, 01 Dec 2017 11:59:00 +0100 New Research School Governance www.cpc-researchschool.orgnews-events/news/news/article/19687/index.html The Research School "Lung Biology and Disease" at the Comprehensive Pneumology Center is a strong structural element in the lung research strategy of the Helmholtz Zentrum München. This field naturally encompasses the Institute of Lung Biology and Disease (ILBD) and Research Unit Lung Repair and Regeneration (LRR), but also lung-focused research in other areas such as the field of epidemiology. To represent all main stakeholders, the governance of the Research School has been adjusted as follows:

 

Program Management

  • Scientific Director: Dr. Claudia Staab-Weijnitz
  • Program Coordinator: Dr. Doreen Franke

The Scientific Director and Program Coordinator are supported by a directorial board that meets regularly to discuss the strategic framework of the CPC Research School. The board is currently composed of

  • Prof. Dr. Silke Meiners, Representative ILBD (Campus Großhadern)
  • Dr. Otmar Schmid, Representative ILBD (Campus Neuherberg)
  • PD Dr. Anne Hilgendorff, Representative Lung Translation
  • Prof. Dr. Dr. Melanie Königshoff, Represenative LRR
  • Prof. Dr. Annette Peters, Representative EPI
  • Dr. Antje Brand, Representative Management
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news-19562 Thu, 30 Nov 2017 10:17:00 +0100 CPC Tandem Grant Writing Challenge www.cpc-researchschool.orgnews-events/news/news/article/19562/index.html The CPC Research School is awarding 10.000 € each for three innovative and creative tandem research projects between two different working groups.

The aim is to support a tandem project between two MD/PhD students or between an MD/PhD student and a postdoc from two different working groups (newly established tandems). Applicants had to submit a proposal (3 pages including a description of the project, a budget plan, and a work/time plan), related to their doctoral/postdoctoral project. Applications were reviewed by the CPC Research School Team and expert reviewers in a blinded manner.

The following projects have been selected for funding:

  • Hani Alsafadi and Michael Gerckens "Screening for small molecule therapeutics for Idiopathic Pulmonary Fibrosis: Analysis of 3D human lung tissue remodeling ex vivo"
  • Andrea Schamberger and Maximilian Strunz "Mapping the cellular hierarchy of distal airway epithelial cells in COPD patients"
  • Carmela Morrone and Salome Rehm "Tissue protective effect of cysteine-protease inhibitors during ex-vivo lung perfusion (EVLP) to prevent subsequent primary graft dysfunction after lung transplantation in mouse model"

Congratulations!

We would like to thank everyone for participating in the CPC Grant Writing Challenge and for submitting so many interesting and thoughtful grant applications.

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news-19563 Thu, 30 Nov 2017 08:30:00 +0100 CPC Research School Grant Writing Challenge www.cpc-researchschool.orgnews-events/news/news/article/19563/index.html Our senior MD and PhD students had the opportunity to participate in a grant writing exercise in order to develop the skills needed to prepare professional, competitive, and successful grant proposals. They had to pick a topic of their choice - related to their MD or PhD projects, e.g. additional experiments or a side project - and write a structured, concise, and clear grant application (4 pages, max. 2000€ budget).

The students put a lot of effort into this exercise and submitted many interesting and thoughtful grant applications. The proposals were reviewed (written reviews) by their peers and a reviewing committee. Afterwards, the students had to present and "sell" their ideas in form of an elevator pitch.

We are happy to announce the awardees of the 2000 € Grant Writing Challenge:

  • Michael Gerckens "Analysis of extracellular matrix deposition in human ex-vivo tissue culture slices for antifibrotic drug validation"
  • Chaido Ori "Direct differentiation of Pluripotent Stem Cells into Lung Progenitor cells - Could a single key transcription regulator be enough?"
  • Thomas Meul "Investigating the immunoproteasome as a signaling hub between dysfunctional mitochondria and MHC I antigen presentation in the absence of intracellular infections"
  • Mario Pepe "Lung adenocarcinoma prognosis : how to rock clinical risk assessment, lead new biomarkers discovery and drug development with a single move"
  • Stefanie Weiß "A new therapeutic approach in ANCA-associated vasculitis: Blocking the autoantigen Proteinase 3"
  • Mehwish Ishaque "STEP TOWARDS NANOMEDICINE: Differential engulfment of nanoparticles by distinct phenotypes of Macrophages M1 and M2"

Congratulations!

Awardees will receive a budget of 2000 € to accomplish their planned experiments.

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news-19749 Mon, 27 Nov 2017 08:36:00 +0100 From OMICS to Systems Biology - Lab exchange at Insybio Ltd www.cpc-researchschool.orgnews-events/news/news/article/19749/index.html After successfully applying for the HELENA Research stay grant, Mario Pepe, Ph.D  student, was awarded with a 3000€ travel grant to fund his lab exchange at the Insybio LTD in Patras, Greece. He worked under the supervision of Professor Seferina Mavroudi and Dr Konstatinos Theofilatos from September 1 till November 1, 2017. Mario had the opportunity to learn new kinds of system biology approaches that strenghten the results of his project, and build new collaborations with the Insybio LTD research department. 

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news-19708 Sun, 19 Nov 2017 11:05:00 +0100 View beyond the horizon – Lab exchange at Shriner’s Hospital for Children www.cpc-researchschool.orgnews-events/news/news/article/19708/index.html After successfully passing the final Research School exam on analyzing scientific articles, Stefan Preisendörfer, MD student, was awarded with a 1000€ travel grant. With this, he was given the opportunity for a lab exchange at the Shriner's Hospital for Children, which is part of the Oregon Health and Science University (OHSU) in Portland, Oregon. He worked under supervision of Hans Peter Bächinger and Yoshihiro Ishikawa in the Research Department from September 1st till October 11, 2017. Stefan performed experiments for his MD thesis, which included in vitro folding of antibodies and circular dichroism spectroscopy measurements. Just one week after coming back to Germany, he presented some of the results in our Research Forum on October 18, 2017.

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news-19561 Fri, 10 Nov 2017 11:32:00 +0100 CPC Career Day 2017 - Register now! www.cpc-researchschool.orgnews-events/news/news/article/19561/index.html You are cordially invited to join us on December 04, 2017 for an interesting and interactive Career Day. Similar to last year's event, we invited speakers who will give an insight into their work and personal career paths, and are open for your questions.

Preliminary program

Please register by sending an email to stefanie.weissnoSp@m@helmholtz-muenchen.de

We are looking forward to seeing you all on December 04, 2017!

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news-19645 Wed, 01 Nov 2017 15:29:00 +0100 PhD Position available - Interactions between oncogenes and innate immunity in lung adenocarcinoma www.cpc-researchschool.orgnews-events/news/news/article/19645/index.html The Lung Carcinogenesis Group of the Comprehensive Pneumology Center (CPC) is now seeking a PhD Candidate "Interactions between oncogenes and innate immunity in lung adenocarcinoma"

Job Description and Requirements

  • Identification and analysis of immune cells in different models of lung adenocarcinoma in mice
  • Handling of and experimentation on transgenic mice expressing or deficient in critical cancer genes
  • Work with cell cultures of primary lung adenocarcinoma cells derived from the lungs of carcinogen-treated mice
  • Analysis of biological responses by molecular immunological and cell biological methods
  • Data-mining in gene and protein-expression data bases linking innate immune response profiles to pathological outcomes
  • Participation and graduation from the CPC Research School, integral member of the Munich Medical Research School (MMRS)
  • Immediate commencement on or shortly after 01.01.2018

Your Qualifications

  • Basic and Master University Degree in Biology, Medicine, or similar discipline
  • Contributing author publication(s) in major biomedical journals
  • Presentation(s) in international conferences and abstracts thereof
  • Excellent practical and theoretical knowledge of molecular biology and immunology
  • Excellent animal experimentation skills, including transgenic mouse work
  • Basic bioinformatics knowledge, including microarray analysis and gene set enrichment analysis
  • Expertise in techniques of cell and molecular biology, including cell culture, FACS, etc.
  • Excellent communication skills in spoken and written English (German not required)
  • High level of motivation, self-dependence, and scientific drive in an international team
  • Willingness to travel for the purposes of the project

Our Offer

  • Three-year initial contract with the possibility for renewal
  • Innovative, well-equipped, and scientifically stimulating environment
  • Mentoring and career development structures
  • Excellent training and educational opportunities
  • Remuneration and benefits in accordance with the collective agreement for the public service (EG 13 50% TV EntgO Bund). In addition, possibility of granting an allowance amounting to 15% if the necessary conditions are fulfilled, especially when other offers for PhD positions have been offered to the candidate.

At the Helmholtz Zentrum München, you can contribute together with leading researchers to the investigation of the development, prevention and treatment of environmental diseases such as diabetes, chronic lung diseases, and allergies. In order to further promote your professional development, we offer extensive and targeted research training and career programmes. We support the reconciliation between work and private life with flexible working time models, occupational health management, day care facility for children, a childcare subsidy, Elder Care, as well as other counseling and support services. The activity involves special knowledge and experience specific to own scientific skills. As holder of the Bavarian Advancement of Women Prize and of the Total E-Quality Certificate, the Helmholtz Zentrum München strives to increase the overall proportion of women on its staff and thus expressly urges qualified women to apply. We look forward to receiving your application via our online application tool.

 

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news-19483 Wed, 25 Oct 2017 08:46:00 +0200 PhD Position available - Identification and analysis of immune cells in different models of pulmonary inflammation in mice www.cpc-researchschool.orgnews-events/news/news/article/19483/index.html The Research Groups "Dynamics of pulmonary inflammation" and "Immunopathology of COPD" at the Institute of Lung Biology and Disease (iLBD) offer a PhD position. Please look here for details and for uploading your application.

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news-19384 Thu, 05 Oct 2017 13:45:00 +0200 MMRS lecture series "Good Scientific Practice" www.cpc-researchschool.orgnews-events/news/news/article/19384/index.html In the upcoming winter semester 2017/18, the MMRS will be offering a lecture series on "Good Scientific Practice". Details here.

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news-19004 Thu, 10 Aug 2017 14:53:00 +0200 5th Munich International Autumn School - Call for applications www.cpc-researchschool.orgnews-events/news/news/article/19004/index.html It is our pleasure to announce the 5th Munich International Autumn School (MIAS), which will take place from December 04 to 08, 2017. The MIAS offers training modules in different labs and clinics in Munich for a limited number of young clinicians and scientists with an MD or PhD background. Participants will hear outstanding lectures given by speakers of the faculty as well as international experts. Plus, they will meet scientists and clinicians from all over the world to share their experiences and ideas. For further information take a look at the flyer or visit our webpage.

Please send your application, including a CV and a list of publications as well as a motivation letter (1/2 page), to research-school@cpc-munich.org until September 15, 2017. Applications will be reviewed by the MIAS organizing committee. Successful applicants will be notified in due time via email.

Costs for accommodation and meals are covered by the CPC Research School and AtemWeg - The Lung Disease Research Foundation, supported by an unrestricted educational grant by Boehringer Ingelheim and the DZL Academy.

Travel costs must be covered by the applicants or their institutions. Fellowships for travel costs may be awarded to selected applicants.

As an additional benefit, we cover the registration fee for the DZL Academy Symposium "In vitro models of lung disease", which will take place in Schloss Hohenkammern on December 09 and 10, 2017. Furthermore, participants are cordially invited to the Career Day organized by the CPC Research School, which will take place on December 04, 2017 and offers another excellent networking opportunity with experts from different fields, providing valuable insights on career development and planning.

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